Author name: JISIASR

Our research group has already extracted bacterial cellulose film (in its pure form) from the A. Xylinus culture as shown in the following Scheme 1. This can serve as potential solution to global plastic waste by proposing an alternative way to make green bioplastic for multiple uses.

In this project (funded by SERB), the fabrication of structurally modified scaffold with biocompatible polymer materials such as chitosan, cellulose, and hyaluronic acid iselectrospunfollowed by bioprintedto guide cell polarization and migration, through which epidermal wound healing may get accelerated. This technology may open up a new possibilities for artificial organ/ skin printing.

A summary of the targeted research in the “Sensors & Materials Laboratory” is shown in the below diagram by mentioning the associated ongoing researches. It covered the basic research on biosensing and bioimaging through the development of 1) Fluorescent Sensors/Probes for Biosensing, and 2) Fluorescent Materials for Bioimaging. Those basic researches on sensing and imaging materials are currently using for the application oriented research towards- 3) Development of sensor device for quality control of environmental samples, and 4) Drug Delivery and Theranostics for Cancer. In short, the research in this group is mainly focused on the development of novel fluorescent sensing materials and probes/sensors/assay kits, and their application for bio-sensing and patho-biological analysis, as well as innovation of sensor technology (in combination with electronics and IoT) for global sustainability.

Protein fibrillation, which has caused a number of diseases and is a hindrance to the biopharmaceutics and protein industries, has emerged as one of the significant issues in the biomedical sector over the past few decades.  Numerous substances, including flavonoids, surfactants, nanoparticles, and micelles, have been widely used as hopeful therapeutic agents to treat amyloidogenic disorders like Alzheimer’s, Parkinson’s, Huntington’s, type 2 diabetes, etc. Membrane disruption, organ malfunction, and apoptosis are all caused by the oxidative damage that fibrillar aggregate deposition causes to cellular membranes. Therefore, it is essential to discover new substances that can block the process of protein fibrillation. Here, our main goal is to create brand-new therapeutics that could revolutionise the way we treat neurodegenerative diseases caused by aggregation. We believe that a thorough understanding of the way in which therapeutic medicines interact with amyloid aggregates at various phases of fibrillation will contribute to a better understanding of the aggregation process’s mechanism. This can be used as a powerful design tool to create brand-new inhibitors that are powerful enough to effectively treat neurodegenerative conditions and advance our understanding of protein aggregation. Our another major research interest is in the field of nanomaterials & drug delivery. The low water solubility and poor bioavailability of certain phenolic chemicals, such as flavonoids, terpenoids, and their metal complexes, limits their use in the biomedical area. The stability and bioavailability of these substances will be improved by encapsulating them in protein- and polymer-based nanoparticulate systems. The creation of innovative nano-formulations is anticipated to offer an efficient means of delivering flavonoids and flavonoid-metal complexes to the desired target site and enhancing their antibacterial and anticancer capabilities. This type of delivery technology benefits from efficient encapsulation, controlled release, precise targeting, and biodegradable characteristics. It will be possible to learn more about medication distribution by seeing how synthesized nano-formulations interact with lipids, nucleic acids, or serum albumins.